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@paradigm_research

Researching the future since 2013

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Recent Posts 20 shown
Post #3457 66
Researchers found that major AI models responded differently to workplace prompts depending on subtle gender-associated language patterns. Across GPT-4, Llama, Gemma and Mistral, prompts containing language more commonly associated with women produced less formal and less complex professional writing than male-associated prompts, even when the user’s name did not signal gender. The findings suggest that linguistic style alone can trigger biased differences in AI-generated workplace communication.

https://arxiv.org/abs/2608.13328
arXiv.org It's How You Ask: Gender-Associated Linguistic Bias in LLMs Professional communication is increasingly mediated by LLMs - but do these models serve all users equally? We show that when prompts contain linguistic features more commonly used by women...
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Post #3456 146
Researchers identified nearly a dozen genes that help planarian flatworms regenerate dopamine-producing neurons after injury. Disrupting some of these genes impaired neuron formation and slowed movement, revealing a genetic program that guides stem cells into the right neural cell types and locations. The findings could inform future strategies for generating dopamine neurons for regenerative therapies.

https://www.nature.com/articles/s41467-026-76397-4
Nature Combinatorial mechanisms specify cellular location and neurotransmitter identity during planarian neurogenesis Nature Communications - During regeneration, new neurons need to be made in a way that reproduces both neuronal diversity and organization. Here the authors show that a combination of factors works...
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Post #3455 154
Researchers developed a noninvasive method to identify senescent “zombie cells” using Raman microscopy combined with single-cell gene expression data. The approach revealed distinctive molecular barcodes, including changes in lipid metabolism, that allowed senescent cells to be detected without destroying them. The method could eventually support diagnostics for aging-related diseases and help evaluate therapies targeting cellular senescence.

https://www.nature.com/articles/s43587-026-01219-7
Nature RamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair Nature Aging - Zhang, Chen, Monticolo, Sorrentino and colleagues pair label-free Raman imaging with spatial and single-cell transcriptomics to probe biochemical signatures of senescence in aging...
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Post #3454 179
Researchers developed a “photonic Lego” approach for integrating different single-crystal materials onto silicon and silicon-nitride photonic chips. Freestanding nanomembranes can be stacked or stitched together using van der Waals forces, adding functions such as electro-optic modulation, magneto-optic isolation and broadband photodetection without conventional lattice-matching constraints. The platform could support more compact multifunctional photonic systems for communications, sensing, computing and quantum technologies.

https://www.nature.com/articles/s41586-026-11000-w
Nature Heterogeneous photonic integration of single-crystalline nanomembranes Nature - A framework consisting of advanced epitaxy and layer lift-off techniques uses heterogeneous photonic integration of single-crystalline nanomembranes to infuse desired functionalities into...
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Post #3453 167
Researchers discovered how some molecular crystals can bend and expand without breaking. Inside the crystals, neighboring molecules act like interconnected “scissors” that open and close in a coordinated way to absorb strain. Crystals with a balanced range of this motion showed large elastic bending and light-driven deformation, while structures already near fully open or closed states were more brittle.

https://onlinelibrary.wiley.com/doi/10.1002/anie.2931090
Wiley Online Library Mechanically Coupled Supramolecular Scissors Govern Photomechanical and Elastic Responses in Molecular Crystals Mechanically coupled supramolecular scissoring links crystal packing geometry to macroscopic mechanical response. Within a homologous crystal series, the initial scissor state governs the balance bet...
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Post #3452 200
Researchers found that flies, mice and humans share a fundamental walking pattern despite major differences in anatomy. Across all three species, joints farther from the body’s center moved faster than more proximal joints, and this distal-to-proximal velocity gradient remained stable even with aging. The findings suggest a conserved principle of motor control and provide a framework for comparing movement, aging and neurological disorders across species.

https://www.pnas.org/doi/10.1073/pnas.2534093123
PNAS Cross-species identification of conserved and divergent locomotor kinematic strategies using AutoGaitA | PNAS Distinct behaviors require the nervous system to execute specialized motor programs, each characterized by unique patterns of body muscle coordinat...
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Post #3451 276
Researchers demonstrated a way to protect quantum information using mechanical vibrations, or phonons, instead of microwave pulses. By continuously driving a silicon-vacancy spin in diamond with sound waves, they created a “dressed” qubit less sensitive to environmental noise and extended its coherence time by about threefold. The same phonons could therefore both carry quantum information and protect it in future chip-scale quantum networks.

https://www.nature.com/articles/s41567-026-03369-2
Nature All-mechanical coherence protection and fast control of a spin qubit Nature Physics - Silicon–vacancy spins can be used in phononic quantum devices, but improvements in coherence times are still required. It has now been shown that the spin coherence can be...
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Post #3450 229
Researchers developed an mRNA immunotherapy that combined five immune-stimulating cytokine mRNAs with three tumor-associated antigen mRNAs to treat pancreatic cancer in mice. About 50% of treated mice achieved complete tumor remission and remained disease-free for up to a year after treatment ended, suggesting the therapy generated durable immune memory against the cancer.

https://www.nature.com/articles/s41467-026-74574-z
Nature Multiplexed cytokine and antigen mRNA administration generates durable anti-tumor immunity against pancreatic cancer Nature Communications - Pancreatic ductal adenocarcinoma (PDAC) displays dismal immunotherapy outcomes in part through a lack of cytokine and antigen signals needed for anti-tumor immunity. The...
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Post #3449 249
Researchers found that an experimental Zika vaccine can protect mice through CD8+ T cells even when antibodies provide no protection. A modified vaccine designed to reduce antibody-dependent enhancement relied entirely on T-cell immunity, but protection disappeared within 12 weeks. The findings suggest future Zika and related flavivirus vaccines may need to generate durable T-cell responses alongside safer antibody immunity.

https://www.nature.com/articles/s41564-026-02465-6
Nature A Zika virus vaccine with E protein fusion loop mutations protects via CD8 [+] T cells Nature Microbiology - A Zika vaccine that minimizes pathogenic antibodies provides short-term protection via CD8+ T cells despite suboptimal neutralizing antibodies, whereas an antibody-centric...
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Post #3448 271
Researchers found that male sex hormones may reduce allergic asthma by strengthening sympathetic nerve connections in the lungs. In mice, androgens promoted nerve growth and norepinephrine release, which suppressed type 2 inflammation; removing male hormones eliminated this protection, while testosterone restored it. The findings suggest a hormone–nerve–immune pathway that may help explain why asthma often improves in males after puberty.

https://www.science.org/doi/10.1126/sciimmunol.aed0186
Science Immunology Androgen signaling via sympathetic neurons regulates allergic pulmonary inflammation Male sex hormones promote lung sympathetic innervation to dampen local allergic responses.
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Post #3447 252
Researchers found that AI models analyzing tumor-infiltrating lymphocytes (TILs) can predict breast cancer outcomes as effectively as human pathologists. Across studies involving more than 5,600 patients with triple-negative and HER2-positive breast cancer, higher TIL levels consistently correlated with better outcomes, while AI also identified spatial immune-cell patterns that provided additional prognostic information.

https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(26)00339-6/abstract
The Lancet Oncology Artificial intelligence-based tumour infiltrating lymphocyte quantification in patients with triple-negative breast cancer: an… Two cTIL models deployed entirely without retraining or modification provided statistically significant prognostic information and improved risk discrimination compared with clinicopathological variables alone in this large, platform-based, independent validation…
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Post #3446 255
Researchers developed an LLM-based closed-loop platform that generates and refines synthesis recipes for new materials using data from 4,407 published experiments. In tests on a previously unreported solid electrolyte, experimental feedback enabled the model to adjust synthesis temperatures from 600°C to 400°C and produce a single-phase material within only a few iterations, reducing trial and error in materials discovery.

https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.74502
The Advanced Portfolio Closed‐Loop Solid‐State Synthesis Planning for Materials Discovery With Large Language Models Leveraging literature data, we build a large-language-model-driven workflow that extracts synthesis steps from 4407 papers, retrieves similar precedents, and generates candidate solid-state synthesis...
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Post #3445 288
Researchers developed a multiregional scaffold that mimics the natural tendon–cartilage–bone interface, providing tissue-specific mechanical and biochemical cues to guide regeneration. In cell and animal studies, the scaffold promoted more organized tendon, cartilage, and bone formation and integrated with existing surgical suture anchors, offering a promising strategy to improve the durability of rotator cuff repairs, particularly for large or degenerative injuries.

https://www.science.org/doi/10.1126/sciadv.aea3128
Science Advances Engineering a biomimetic multiphasic suture anchor system for enhanced rotator cuff enthesis regeneration The rotator cuff plays a vital role in shoulder movement and joint stability. Unfortunately, tears at the rotator cuff enthesis are common and frequently lead to retears after surgical intervention, particularly at the suture location and its anchor ...
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Post #3444 243
Researchers discovered that samarium-based infinite-layer nickelates exhibit reentrant superconductivity, where superconductivity is first suppressed by a magnetic field but then re-emerges and persists beyond 60 tesla. The effect, attributed to the Jaccarino–Peter compensation mechanism, allows superconductivity to survive under extreme magnetic fields, offering a potential route to high-field superconducting magnets, quantum devices, and future high-temperature superconductors.

https://www.nature.com/articles/s41467-026-75922-9
Nature High-field-stabilized reentrant superconductivity in infinite-layer nickelate thin films Nature Communications - The authors demonstrate high-magnetic-field-stabilized re-entrant superconductivity in infinite-layer nickelate thin films. They show that both the low-field and high-field...
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Post #3443 306
Researchers found that dogs blink more frequently when watching humans blink, especially their owners, suggesting blinking functions as a subtle social signal. While dogs did not directly synchronize individual blinks, increased blink rates in response to familiar people indicate that blinking may play a role in social attention, communication, and human–dog bonding.

https://royalsocietypublishing.org/rsos/article/13/8/rsos260512/483035/Blinking-together-the-modulation-of-eye-blinking
The Royal Society Blinking together: the modulation of eye blinking in dog–human social contexts Abstract. Eye blinking and its synchronization have been associated with shared attention, interpersonal connection and physiological rhythms in humans. Ho
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Post #3442 312
Researchers assembled near-complete genomes of eight Myotis bat species and found that evolutionary adaptations to viral defense overlap with genes involved in DNA repair, longevity, and cancer resistance. The study identified unique immune gene copy-number expansions (including PKR) that enhance antiviral responses and damaged-cell elimination, suggesting that bats' exceptional lifespan and low cancer rates may arise from shared genetic mechanisms connecting immunity, aging, and genome maintenance.

https://www.nature.com/articles/s41586-026-10932-7
Nature Insights into longevity and virus-driven adaptation from Myotis bat genomes Nature - Comparative and functional analyses of Myotis bats uncover unique patterns of adaptation in virus-interacting proteins and longevity-associated pathways, linking two hallmarks of bat biology.
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Post #3441 265
Researchers developed Nano-ERASER, a nanoparticle system that crosses the blood-brain barrier and converts astrocytes into functional neurons by degrading the PTBP1 protein without altering DNA. In human brain organoids and mouse Alzheimer's models, the treatment restored neural circuits, reduced neuroinflammation and amyloid-beta accumulation, increased neuron density, and improved memory and learning, highlighting a promising regenerative approach for Alzheimer's disease.

https://www.cell.com/cell-biomaterials/fulltext/S3050-5623(26)00231-X
Cell Biomaterials Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration Neurodegeneration in Alzheimer’s disease outpaces the brain’s ability to regenerate neurons. Wang et al. develop a Nano-ERASER platform that delivers anti-PTBP1 antibodies into astrocytes, enabling proteasome-mediated PTBP1 degradation and activating neuronal…
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Post #3440 276
Researchers used quantum logic spectroscopy and a Schrödinger's cat entangled state to detect the tiny recoil from a single infrared photon absorbed by a single calcium hydroxide molecule. The technique enabled the first nondestructive infrared spectrum of an individual molecule, opening new possibilities for high-precision molecular spectroscopy, quantum chemistry, and quantum technologies.

https://www.nature.com/articles/s41586-026-10915-8
Nature Infrared absorption spectroscopy of a single polyatomic molecular ion Nature - Non-destructive single-molecule absorption spectroscopy is achieved by detecting photon recoil from a trapped molecular ion, enabling single-photon-sensitive measurements of molecular...
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Post #3439 246
Researchers developed a new family of Aurivillius-type oxide-ion conductors that achieve high ionic conductivity at just 350°C, well below the operating temperature of conventional solid oxide fuel cells. The optimized magnesium-doped layered film created fast ion-conducting channels and enabled fuel cells to reach a power density of 0.726 W/cm² at 400°C with stable operation, offering a pathway toward more durable, lower-cost hydrogen fuel cells with simpler thermal management.

https://www.nature.com/articles/s41560-026-02115-5
Nature Low-temperature oxide-ion conduction in Aurivillius-type ((Na0.5Bi0.5)n–1TinO3n)(Bi2O2) phases Nature Energy - Solid oxide-ion conductors are essential for high-temperature electrochemical technologies, yet few materials maintain sufficient ion mobility at lower temperatures, where...
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Post #3438 234
Researchers developed a tellurium-hyperdoped silicon photodiode that detects short-wave infrared (SWIR) light using standard CMOS-compatible manufacturing. By combining hyperdoping with light-trapping micro-pyramids and a gold reflector, the device achieved record room-temperature detectivity (4×10¹⁰ Jones) and ~85% light absorption, paving the way for inexpensive SWIR cameras for smartphones, autonomous vehicles, medical imaging, and industrial sensing.

https://journals.aps.org/prl/abstract/10.1103/96rx-zx6l
Physical Review Letters Breakthrough in Short-Wavelength Infrared Quantum Efficiency in Te-Hyperdoped Silicon Photodetectors via Light-Trapping Strategies A new light-trapping architecture could lead to CMOS-compatible night-vision technology.
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