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Researchers developed Nano-ERASER, a nanoparticle system that crosses the blood-brain barrier and converts astrocytes into functional neurons by degrading the PTBP1 protein without altering DNA. In human brain organoids and mouse Alzheimer's models, the treatment restored neural circuits, reduced neuroinflammation and amyloid-beta accumulation, increased neuron density, and improved memory and learning, highlighting a promising regenerative approach for Alzheimer's disease.

https://www.cell.com/cell-biomaterials/fulltext/S3050-5623(26)00231-X
Cell Biomaterials Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration Neurodegeneration in Alzheimer’s disease outpaces the brain’s ability to regenerate neurons. Wang et al. develop a Nano-ERASER platform that delivers anti-PTBP1 antibodies into astrocytes, enabling proteasome-mediated PTBP1 degradation and activating neuronal…
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