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Researchers identified nearly a dozen genes that help planarian flatworms regenerate dopamine-producing neurons after injury. Disrupting some of these genes impaired neuron formation and slowed movement, revealing a genetic program that guides stem cells into the right neural cell types and locations. The findings could inform future strategies for generating dopamine neurons for regenerative therapies.

https://www.nature.com/articles/s41467-026-76397-4
Nature Combinatorial mechanisms specify cellular location and neurotransmitter identity during planarian neurogenesis Nature Communications - During regeneration, new neurons need to be made in a way that reproduces both neuronal diversity and organization. Here the authors show that a combination of factors works...
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