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Researchers developed a noninvasive method to identify senescent “zombie cells” using Raman microscopy combined with single-cell gene expression data. The approach revealed distinctive molecular barcodes, including changes in lipid metabolism, that allowed senescent cells to be detected without destroying them. The method could eventually support diagnostics for aging-related diseases and help evaluate therapies targeting cellular senescence.

https://www.nature.com/articles/s43587-026-01219-7
Nature RamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair Nature Aging - Zhang, Chen, Monticolo, Sorrentino and colleagues pair label-free Raman imaging with spatial and single-cell transcriptomics to probe biochemical signatures of senescence in aging...
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