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Researchers found that an experimental Zika vaccine can protect mice through CD8+ T cells even when antibodies provide no protection. A modified vaccine designed to reduce antibody-dependent enhancement relied entirely on T-cell immunity, but protection disappeared within 12 weeks. The findings suggest future Zika and related flavivirus vaccines may need to generate durable T-cell responses alongside safer antibody immunity.

https://www.nature.com/articles/s41564-026-02465-6
Nature A Zika virus vaccine with E protein fusion loop mutations protects via CD8 [+] T cells Nature Microbiology - A Zika vaccine that minimizes pathogenic antibodies provides short-term protection via CD8+ T cells despite suboptimal neutralizing antibodies, whereas an antibody-centric...
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