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Programming Multicellular Assembly with Synthetic Cell Adhesion Molecules (Nature 2022 UCSF)
a wide array of synthetic cell adhesion molecules (synCAMs) can be generated by combining orthogonal extracellular interactions with intracellular domains from native adhesion molecules, such as cadherins and integrins.
They can be used to mimic the cell-cell interactions with adhesion properties similar to native interactions and then enables rationally programmed assembly of novel multicellular architectures, as well as systematic remodeling of native tissues