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A Model for Cleavage Plane Determination in Early Amphibian and Fish Embryos (Current Biology 2010 Tim Mitchison)
metaphase spindles are positioned and oriented by interactions of their astral microtubules with the cellular cortex, followed by cleavage in the plane of the metaphase plate
a model to explain cleavage plane geometry in which the length of astral microtubules is limited by interaction with these boundaries, causing length asymmetries - Dynein anchored in the cytoplasm then generates length-dependent pulling forces, which move and orient centrosomes