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Regulation of cytokinesis by Rho GTPase flux
Rho activation by guanine nucleotide exchange factors (GEFs) - initiation
Rho inactivation by GTPase activating proteins (GAPs) - termination
MgcRacGAP: a conserved cytokinesis regulator thought to be required only at the end of cytokinesis
This paper: GAP activity of MgcRacGAP is necessary early during cytokinesis for the formation and maintenance of the Rho activity zone
 the GAP domain of MgcRacGAP has two unexpected roles throughout cytokinesis：
1. it transiently anchors active Rho
2. it promotes local Rho inactivation, resulting in the constant flux of Rho through the GTPase cycle

centralspindlin complex: kinesin MKLP-1 and the Rho GAP MgcRacGAP - activate Rho through Ect2, a Rho GEF that binds MgcRacGAP