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Post #503 121
12/7
Rho GTPases in animal cell cytokinesis: An occupation by the one percent (Cytoskeleton (Hoboken) 2012)

Rac1 is a negative regulator of cytokinesis
inactivated within the division plane
actived in the cell poles
Cdc42 is also required
RhoA - binds to GTP (active); binds to GDP (inactive)
RhoA localizes to equatorial membrane before cell division occurs
RhoA protein accumulates at the division plane before the cell begins to divide
It is hypothesized that spindle microtubules dictate the site of cell division by specifying RhoA activation. Indeed, following microtubule depolymerization, GTP-bound RhoA does not properly localize to the cell equator
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