🇲🇽 Mexico City is mostly Indigenous, genetically

DNA from Mexico City shows people are, on average, about two-thirds Indigenous and about one-third European, with a small African component.

The X chromosome carries more Indigenous ancestry than the rest of the genome, which fits a history with more Indigenous women and more European men contributing to today’s population.

The dataset also helps make medical genetics work better for people with high Indigenous Mexican ancestry.

Takeaway: Mexico City’s genome reflects a predominantly Indigenous heritage shaped by sex-biased mixing during and after colonization.

Source: Ziyatdinov et al., 2023. Genotyping, sequencing and analysis of 140,000 adults from Mexico City.