In the first phase
of hypnosis, during the induction, the subject’s attention on an object stimulates fronto-limbic structures, which are inhibited and/or dissociated in the second phase. In the third phase, right-sided temporo-posterior regions are stimulated. In response to hypnosis, the fronto-cortical activity is reduced and the dorsolateral prefrontal cortex structures are dissociated and the cingulate activity increases or decreases depending on the suggestions. Hypnotic responding demonstrates greater dominance in the right hemisphere than left hemisphere processing, associated with cognitive activities while no difference is found in hypnotizability between left and right hemisphere lesions. Highs have significantly larger rostrum than lows. Hypnosis influences the connectivity between brain regions. The connectivity is decreased between frontal midline areas and left lateral scalp sites in highs while increased between left temporal and right occipital areas in lows. Areas and type of activity changes in the brain depend on the suggestions, rather than hypnosis per se. Highs are more prone to hypnotic suggestions by higher levels of theta activity and structural connectivity between left and right hemisphere frontal areas. Reducing frontal activity increases the response to hypnotic suggestions and not a general hypnotic responsivity.

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