🇮🇷👌 Iran Develops Homegrown Nuclear-Medicine Drug for Cancer Diagnosis

Iranian researchers trying to develop a cancer-imaging radiopharmaceutical ran into a basic problem: they could not obtain even a single foreign vial to use as a reference sample.

So the development team had to work out the product themselves.

The result is an Iranian version of Technetium-99m tilmanocept, a radiopharmaceutical used to map the lymphatic system and identify sentinel lymph nodes during cancer diagnosis and surgery.

After injection, the compound accumulates in lymphatic tissue and helps doctors locate the first nodes draining a tumor. Those nodes can then be examined for signs that cancer has begun to spread.

The product is internationally marketed as Lymphoseek.
According to the Iranian developer, its researchers spent around six months working through the formulation and production process using reverse engineering after attempts to obtain a foreign reference vial failed.

An initial version was produced about a year and a half ago and supplied to the Atomic Energy Organization of Iran. The product is now in the final stages of clinical trials, with commercialization planned by March 2027.

The company estimates domestic production could save Iran around $25M in foreign currency by replacing imported supply.

Tilmanocept is a relatively specialized product compared with conventional pharmaceuticals. Developing it requires pharmaceutical chemistry, radiolabeling know-how, quality control and the ability to integrate the compound into nuclear-medicine procedures.

That makes the project part of a wider expansion of Iran’s domestic radiopharmaceutical sector.

Iranian officials say another 20 radiopharmaceuticals are currently in research and development, while the country is also preparing an indigenous alpha-emitting treatment for advanced cancers.

The tilmanocept project shows how that capability is moving into narrower, higher-value products that Iran previously had to source abroad.

In this case, the lack of access went as far as a single reference vial. Iranian researchers still managed to reproduce the product and move it into clinical testing.

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