As Parkinson's disease progresses, harmful protein clumps build up in the brain, blocking communications between neurons and killing them off – but what if we could prevent these clusters from forming?

Researchers led by a team from the University of Bath in the UK have achieved just that in a basic worm model of Parkinson's. They engineered a peptide, a small amino acid chain, to essentially keep a protein called alpha-synuclein locked in its healthy shape. This prevented the misfolding that leads to clumps.

The potential treatment checks several important boxes: it's durable, and it can survive inside cells without causing any toxic side effects.

"This opens an exciting path towards new therapies for Parkinson's and related diseases, where treatment options remain extremely limited," says biochemist Jody Mason, from the University of Bath.

The study follows on from previous work by some of the same researchers, which identified part of the alpha-synuclein protein that may stop it building to dangerous levels. This key part or fragment acts like a guide for the protein to follow.