To help mitigate climate change, companies are using bioreactors to grow algae and other microorganisms that are hundreds of times more efficient at absorbing CO2 than trees. Meanwhile, in the pharmaceutical industry, cell culture is used to manufacture biologic drugs and other advanced treatments, including lifesaving gene and cell therapies.

Both processes are hampered by cells' tendency to stick to surfaces, which leads to a huge amount of waste and downtime for cleaning. A similar problem slows down biofuel production, interferes with biosensors and implants, and makes the food and beverage industry less efficient.

Now, MIT researchers have developed an approach for detaching cells from surfaces on demand, using electrochemically generated bubbles. In an open-access paper published in Science Advances, the researchers demonstrated their approach in a lab prototype and showed it could work across a range of cells and surfaces without harming the cells.

"We wanted to develop a technology that could be high-throughput and plug-and-play, and that would allow cells to attach and detach on demand to improve the workflow in these industrial processes," says Professor Kripa Varanasi, senior author of the study. "This is a fundamental issue with cells, and we've solved it with a process that can scale. It lends itself to many different applications."