Annie is a New York Times bestselling author, who also wrote the book ‘Nuclear War.’

The scenario in Annie Jacobsen’s Biological War: A Scenario is a fictional, minute-by-minute account of an accidental release of an engineered pathogen that spreads globally and collapses civil order within days.

The lab accident takes place in Siberia. Reviews and Jacobsen’s own interviews describe the released agent as a genetically modified form of Yersinia pestis, the bacterium that causes pneumonic plague, engineered for high airborne transmissibility and lethality.

From there the narrative tracks rapid international spread, including Los Angeles and Frankfurt before authorities can confirm the source or contain it.

The book then follows U.S. and international responses, intelligence agencies, the White House, CDC, WHO, as hospitals, supply chains, and civil authority break down, ending in widespread anarchy and a severely depopulated, militarized aftermath.

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