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📄 Unanticipated intermediates during isopenicillin N synthase catalysis identified by time-resolved X-ray free-electron laser studies

📝 مطالعه با XFEL و طیف‌سنجی، واسطه‌های ناشناخته در کاتالیز isopenicillin N synthase و مسیر تشکیل پنی‌سیلین با Fe(IV) را نشان می‌دهد.

📚 Journal: Nature Catalysis #NatureCatalysis
📅 Date: 2026-10-09
🔬 Research Article | 🔓 Open Access | 📥 PDF
🔗 10.1038/s41929-026-01618-4

🏷 isopenicillin N synthase · X-ray free-electron laser · time-resolved crystallography · penicillin biosynthesis · Fe(IV) intermediate
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