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Post #74404 3
📄 Semisynthesis of Multiphosphorylated and Acetylated Histone Methyltransferase Dot1L Reveals Synergistic Inhibition of Nucleosomal H3K79 Methylation

📝 روش نیمه‌سنتزی برای ساخت Dot1L با فسفریلاسیون و استیلاسیون چندگانه، مهار هم‌افزای متیلاسیون H3K79 نوکلئوزومی را نشان داد.

📚 Journal: Journal of the American
Chemical Society #JACS
📅 Date: 2026-10-05
🔬 Research Article
🔗 10.1021/jacs.6c07839

🏷 Dot1L · histone methylation · semisynthesis · post-translational modifications · nucleosome
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