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Post #74066 48
📄 Tumor cell–intrinsic stress states drive sensitivity to CAR T cell therapy in pancreatic cancer

📝 صفحه‌های CRISPR درون‌تنی نشان می‌دهند اختلال در Keap1 و Slc33a1 و فعال‌سازی Nrf2، تومورهای پانکراس را به کشندگی CAR T حساس می‌کند.

📚 Journal: Science Advances #ScienceAdvances
📅 Date: 2026-10-02
🔬 Research Article
🔗 10.1126/sciadv.aeh8973

🏷 CAR T cell therapy · pancreatic cancer · CRISPR screens · oxidative stress · Keap1-Nrf2
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