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📄 Aging-associated SATB1 deficiency remodels 3D genome architecture and transcriptional programs in naive CD4 + T cells

📝 کاهش SATB1 با افزایش سن، معماری سه‌بعدی ژنوم و برنامه رونویسی سلول‌های T CD4+ ساده را بازآرایی کرده و ژن‌های التهابی را فعال می‌کند.

📚 Journal: Science Advances #ScienceAdvances
📅 Date: 2026-10-02
🔬 Research Article
🔗 10.1126/sciadv.aeg1622

🏷 SATB1 · 3D genome · naive CD4 T cells · TAD boundaries · aging
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