Chinese scientists find genetic switch for organ regeneration in mammals

Breakthrough in regenerative medicine from Chinese researchers at NIBS and BGI Research. Publication in Science showed how to restore healing ability in mammals.

The key is the Aldh1a2 gene, responsible for vitamin A metabolism. In fish and salamanders, it is active, but in mammals, it is blocked by evolution.

Scientists "switched on" this gene in mice and rats, leading to complete regeneration of soft and joint tissues. The mechanism works through the production of retinoic acid.

This discovery could simplify the treatment of bone, limb, skin, nerve, and lung injuries in humans.

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