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生物医学科技前线 生物医学科技前线 @sci_feed · 644 subscribers
Post #4661 55
科学家们终于揭开了为什么有前景的抗癌药物总是会失败的原因
研究人员发现，曾经被认为是突破性的的BET抑制剂类药物在实际临床应用中经常会失效。新的研究揭示了一个关键原因：两个相关蛋白质BRD2和BRD4并不执行相同的工作。相反，BRD2像是一个“舞台经理”，为基因的激活做准备，而BRD4则触发激活基因…
来源: ScienceDaily ｜ 阅读全文
发布时间: 2026-04-10 11:42 GMT+8（北京时间）
#BET抑制剂 #癌症 #BRD2 #BRD4
ScienceDaily Scientists finally uncover why promising cancer drugs keep failing Cancer drugs known as BET inhibitors once looked like a breakthrough, but in real patients they’ve often fallen short. New research reveals a key reason why: two closely related proteins, BRD2 and BRD4, don’t actually do the same job. Instead, BRD2 acts like…
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