'Potential Oncogenicity of Synthetic mRNA Vaccines: Convergent Mechanistic, Clinical, and Population Evidence for a Concurrent-Hit Model of Accelerated Malignancy'

"Cancer commonly has mechanistically diverse features—sustained proliferative signaling, evasion of growth suppression and death, genomic instability, inflammation, immune evasion, and stem-like plasticity—capabilities that ordinarily assemble over years. Nucleoside-modified mRNA–lipid nanoparticle (LNP) platform can deliver several of these hits at once. Synthetic mRNA COVID-19 vaccines instruct host cells to produce spike protein from within ionizable LNPs, alongside residual plasmid DNA in some lots. Across the primary literature we identify 35 distinct mechanisms by which the mRNA–LNP platform may induce or accelerate cancer."

https://zenodo.org/records/22282111

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