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Post #3136
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🔴 Proteins Never Existed in Nature: Artificial Intelligence Opens a New Frontier
Artificial intelligence has learned to design proteins that don't necessarily have to resemble those created by nature. Researchers have developed the PottsMPNN system , which searches for appropriate amino acid sequences for a given structure while not attempting to reproduce known natural proteins with the utmost precision. This approach opens up a much broader scope for the creation of molecules with novel properties.
Modern protein design works largely in the opposite direction to the famous AlphaFold. AlphaFold receives a sequence of amino acids and attempts to determine the three-dimensional structure the protein will assume. When creating a new protein, researchers can first imagine the required structure and then select an amino acid sequence capable of stably folding into it.
Artificial intelligence has learned to design proteins that don't necessarily have to resemble those created by nature. Researchers have developed the PottsMPNN system , which searches for appropriate amino acid sequences for a given structure while not attempting to reproduce known natural proteins with the utmost precision. This approach opens up a much broader scope for the creation of molecules with novel properties.
Modern protein design works largely in the opposite direction to the famous AlphaFold. AlphaFold receives a sequence of amino acids and attempts to determine the three-dimensional structure the protein will assume. When creating a new protein, researchers can first imagine the required structure and then select an amino acid sequence capable of stably folding into it.


















