Aplasia cutis congenita is a condition in which there is congenital (present from birth) absence of skin, with or without the absence of underlying structures such as bone. It most commonly affects the scalp, but any location of the body can be affected. While most people with Aplasia cutis congenita have no other abnormalities, some people have congenital malformations involving the cardiovascular, gastrointestinal, genitourinary, and central nervous systems. The cause of this condition is unclear and appears to be multifactorial; contributing factors may include teratogens, genes, trauma, and compromised blood flow to the skin.

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