Researchers at Duke-NUS Medical School, together with international collaborators, have produced one of the most detailed single-cell maps of the developing human brain to date. This atlas catalogues almost every type of brain cell, documents their genetic signatures, and shows how they grow and communicate with one another. It also evaluates leading laboratory techniques used to generate high-quality neurons, representing a key advance toward new treatments for Parkinson’s disease and other neurological conditions.

Why Parkinson’s disease is a central focus
Parkinson’s disease is the second most common neurodegenerative disorder in Singapore and affects roughly three in every 1,000 people aged 50 and above. The disease destroys midbrain dopaminergic neurons—the cells responsible for releasing dopamine, a chemical essential for movement control and learning. Replacing or restoring these damaged cells could eventually help reduce symptoms such as tremors and loss of mobility.