“I got the COVID vaccine and nothing bad ever happened to me," is a comment you have likely heard.

But that experience doesn’t tell us what happened to someone who received a different batch.

As @P_McCulloughMD explains in this clip, the 2023 analysis by Max Schmeling and colleagues found that just 4.2% of COVID vaccine batches accounted for 71% of suspected adverse events. Other batches had remarkably few reports.

Early in the rollout, my colleagues and I noticed that patients reported either quite strong reactions or almost none. I suspected that difficulties manufacturing the mRNA vaccines at scale were producing substantial differences between lots.

But vaccine “hot lots” aren't a new problem.

When I reviewed the historical records, what struck me was how closely these concerns mirrored a century of forgotten vaccine disasters

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