This article explores the integration of Varnish with Istio in a Kubernetes environment to achieve efficient caching and load balancing. By leveraging Istio's consistent hash-based load balancing, Varnish instances can be optimized to handle requests of the same type, ensuring that equivalent requests are routed to the same Varnish instance, thus maintaining high cache effectiveness and reducing latency.

https://medium.com/hamburger-berater-team/varnish-sharding-with-istio-in-kubernetes-402f313919aa