Gemma C2S-Scale 27B helped scientists to analyze gene activity in cells and find for substances to enhance immune response against tumors. (Google-Calico)
🔴 What is the challenge?
Many tumors remain "cold". the immune system "does not notice" them. To reverse this, antigen presentation needs to be triggered, but precisely, only where there is already a weak immune signal, not in all cells indiscriminately.
Gemma was able to predict that a combination of the drug silmitasertib (a CK2 inhibitor) and a low dose of interferon increases MHC-I expression. This makes “cold” tumors more visible to the immune system.
🟢 What Laboratory test results confirmed?
- the model's prediction confirmed by the lab test with combined application indeed enhanced antigen activity by about 50%, and this could become the basis for new types of immunotherapy.
The main achievement: AI not only accelerated data analysis but formulated a new scientific hypothesis that was confirmed in real experiments.
Its an example of how large models go beyond text generation and begin to discover new drugs-mechanisms of action.
More details on Github too
#AI #GoogleDeepMind #BioTech
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