COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

نخستین کنگره علمی دانشجویی میان‌رشته‌ای ارتوپدی (COTARIUM2025) در تاریخ ۴ بهمن ماه ۱۴۰۳ با شور و شعف علمی دانشجویان و حضور اساتید گران‌قدر و قدردانی از برگزیدگان به ثمر نشست.

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❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 The role of lateral wall reconstruction in improving surgical outcomes for intertrochanteric femur fractures

👥 Sanaz Bordbar, Mehdi Komijani*, Fereshteh Eidy, Mohammad Hossein Nabian, Leila Zanjani

📔 Journal of Experimental Orthopaedics (Q1)

🗓 August 2025

🗂 Systematic Review

📄 Abstract:

Purpose: Intertrochanteric fractures are the most common type of proximal femur fractures, with lateral wall fractures occurring in approximately 33% of cases. This meta-analysis compared the effectiveness of intramedullary fixation methods, specifically the proximal femoral nail (PFN) and the proximal femoral nail anti-rotation (PFNA), to other treatment options.

Methods: A systematic review was conducted using PubMed, Scopus, Web of Science and Embase, following PRISMA guidelines. We included clinical trials on intertrochanteric femur fractures with lateral wall involvement. Random effects models were used to analyze mean differences across treatment methods, with statistical evaluations including I², Cochran’s Q, sensitivity analyses, and Egger’s test. Additionally, a subgroup analysis was performed.

Results: Of the initial 1009 results, 10 studies involving 516 patients were included. The surgical methods assessed included PFN/PFNA, PFN with trochanteric buttress plates, screw-augmented PFN, PFNA with a sliding compression plate and InterTan. Blood loss was significantly greater in the experimental models (MD: 31.83, 95% confidence interval [CI]: 0.28-63.38, p < 0.001, I² = 99%). Union time was reduced in the experimental models (MD: -0.60, 95% CI: -0.95 to -0.24, p = 0.18, I² = 42%). The Harris hip score (HHS) was also higher (MD: 7.03, 95% CI: 4.81-9.26, p = 0.74, I² = 0%).

Conclusion: Combining PFN with lateral wall reconstruction techniques may increase blood loss, decrease union times, and improve functional outcomes, suggesting advantages over PFN or PFNA alone.

🔗 https://doi.org/10.1002/jeo2.70385

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🆔 @COTAR_TUMS

❇️ انتشار #مقاله جدید با وابستگی کوتار

✏️ محصول مدرسه مرور نظام‌مند

💠 Abutment Margin Level and Residual Cement Around the Dental Implant: A Systematic Review and Meta-Analysis

👥 Sara Moradianlotfi, Atieh Tavasol, Amirhossein Mohammadi, Fereshteh Eidy, Ali Babaei Zarch, Amir Kasaeian, Shirin Djalalinia, Marzieh Alikhasi

📔 European Journal of Prosthodontic & Restorative Dentistry (Q2)

🗓 August 2025

🗂 Review

📄 Abstract:

Background: Excess cement around implant-supported fixed restorations is a major problem that can lead to implant-related and aesthetic complications. Different abutment margin levels have been associated with the amount of residual cement.
Methods: A comprehensive search was performed in Medline/PubMed, Scopus, Web of Science, EMBASE, and Cochrane up to June 2023, using the PICO framework. Titles, abstracts, and full texts were independently screened by two authors. Risk of bias was assessed via the QUIN tool and ROBINS-I. A random-effects meta-analysis model was used.
Results: Twelve studies were included. Abutment margin levels considered included: 1 mm supragingival, at gingival level, 1 mm subgingival, and 3 mm subgingival. The combined mean excess cement for abutment margins of 1 mm supragingival was 0.04 ± 0.05 (I²=84%), at the gingival level 1.09 ± 2.0 (I²=49%), and 1 mm subgingival 1.18 ± 6.21 (I²=95%). The overall proportion of excess cement for abutment margins 1 mm subgingival and 3 mm subgingival were 0.26 (95% CI: 0.21-0.30) and 0.29 (95% CI: 0.25-0.34), respectively.
Conclusion: The level of the abutment margin is significantly associated with residual cement. Wherever possible, placing the abutment margin more gingivally or even supragingivally is advisable.

🔗 https://pubmed.ncbi.nlm.nih.gov/40748496/

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🆔 @COTAR_TUMS

️ انتشار #مقاله جدید با وابستگی کوتار

💠 Effects of isometric vs. dynamic resistance training on isometric and isokinetic muscular strength: A systematic review with meta-analysis

👥 Morteza Ghayomzadeh*, Jiuzhang Li, Fereshteh Eidy, Mohammad Keshavarz, Angelo Sabag, Ché Fornusek, Daniel A. Hackett

📔 Journal of Science and Medicine in Sport (Q1)

🗓 August 2025

🗂 Review

📄 Abstract:

Both isometric resistance training (ISO-RT) and dynamic resistance training (DYN-RT) are widely used to enhance muscular strength. This systematic review and meta-analysis compared the effects of ISO-RT versus non-exercise controls and DYN-RT on isometric and isokinetic strength in healthy adults. A total of 32 studies with 621 participants were included. ISO-RT significantly improved strength compared to controls (SMD = 0.65; 95% CI: 0.52-0.77) and compared to DYN-RT (SMD = 0.35; 95% CI: 0.21-0.48). Subgroup analyses showed greater improvements in isometric strength with ISO-RT compared to DYN-RT, while isokinetic strength gains were similar between the two. Findings suggest ISO-RT is an effective alternative or complement to DYN-RT for building muscular strength.

🔗 https://doi.org/10.1016/j.jsams.2025.07.011

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🆔 @COTAR_TUMS

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Limited Efficacy of Pharmacological Interventions for Improving Postoperative Sleep Quality in Primary Total Joint Arthroplasty Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

👥 Negarsadat Namazi, Ali Salmani, Ariyan Ayati, Amir Mehrvar*, Mohammad Poursalehian, Sina Hajiaghajani

📔 Journal of Arthroplasty (Q1)

🗓 September 2025

🗂 Systematic review

📄 Abstract:

Background: Sleep disturbances are prevalent after primary total joint arthroplasty (TJA), yet the effectiveness of pharmacological interventions remains unclear.
Methods: We conducted a systematic review and meta-analysis of randomized controlled trials evaluating pharmacological interventions for sleep quality in TJA patients.
Results: Twenty-four RCTs comprising 2,934 patients were included. Zolpidem significantly improved sleep quality up to 3 weeks postoperatively (Hedges’ g = −1.51; P < .001). Antiepileptics were also effective (Hedges’ g = −0.603; P < .001) but were associated with more adverse effects. Melatonin and corticosteroids did not show significant efficacy.
Conclusions: Evidence suggests limited efficacy of pharmacological interventions, with zolpidem providing short-term benefits but safety concerns restricting its routine use. Further high-quality studies are warranted.

🔗 https://doi.org/10.1016/j.arth.2025.08.071

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🆔 @COTAR_TUMS

🎇 مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی (COTAR) برگزار می‌کند:

📚 سلسله ژورنال کلاب‌های میان‌رشته‌ای | COTAR COLLAB

🔖 موضوع جلسه ششم:
A Survey of Artificial Intelligence in Gait-Based Neurodegenerative Disease Diagnosis

📆 سه شنبه ۱۸ شهریور ۱۴۰۴
⏰ ساعت ۱۲ الی ۱۳
🏛 بیمارستان شریعتی، معاونت آموزشی، کلاس سینا
💻 لینک مجازی:
cotar.tums.ac.ir/webinar

👥 گرداننده: دکتر محمدحسین نبیان (ریاست کوتار)

✏️ ارائه‌دهنده: دکتر سپهر متانت

🧁 همراه با پذیرایی و شبکه‌سازی پس از جلسه

🔅 حضور تمامی دانشجویان و پژوهشگران علاقه‌مند گرامی داشته می‌شود.

❇️ انتشار #مقاله جدید با وابستگی کوتار توسط انتشارات Nature

✏️ محصول مدرسه مرور نظام‌مند

💠 Neuroregenerative and neuroprotective effects of bioengineered scaffolds in spinal cord injury: a systematic review of preclinical and early phase clinical studies

👥 Armin Khavandegar, Negin Safari Dehnavi, Mario Ganau, Zahra Ramezani, Elaheh Khodadoust, Mahgol Sadat Hassan Zadeh Tabatabaei, Tahereh Maleki, Maryam Alsadat Mousavi, Kimia RayatSanati, Mahsa Esmaeili, Ayda Eslami Nejad Parizi, Amgad S Hanna, Zahra Hassannejad, Michael G Fehlings, Mahdi Sharif-Alhoseini*

📔 Spinal Cord (Q1)

🗓 August 2025

🗂 Systematic review

📄 Abstract:

Objectives
To systematically examine the use of bioengineered scaffolds, with/without bioactive agents, drugs, or cellular transplants in preclinical animal models and human studies of spinal cord injury (SCI).
Setting
Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences
Methods
A systematic review and meta-analysis was conducted following PRISMA guidelines and registered in PROSPERO (ID: CRD42023437266). A comprehensive search in MEDLINE and Embase on 8/27/2023 identified studies on scaffolds as neuroregenerative and neuroprotective treatments for SCI. Human studies were assessed using ROBINS-I, and meta-analysis focused on clinical outcomes.
Results
Of 4561 articles screened, 931 studies were included: in-vivo (82%), in-vitro (16%), and human studies (1%). Various biomaterials (N = 82; natural: 38%; synthetic: 62%), cell types (N = 27; NSCs: 24%, Schwann cells: 13%, NPCs: 12%), bioactive agents (N = 38; NT-3: 32%, BDNF: 25%, FGF: 24%), and pharmacological agents (N = 88; chABC: 12%, heparin: 11%, taxels: 10%) were analyzed. Fourteen human studies included acute and chronic SCI patients, with cervical (36%) and thoracic SCI (64%). Clinical trials demonstrated moderate to low quality (ROBINS-I). Our meta-analysis indicated that the pooled 2-scale AIS conversion rate was 30.59% (p = 0.005) ranging from 33.46% (p = 0.036) in acute to 28.35% (p = 0.084) in chronic SCI. Furthermore, the pooled 1-scale AIS conversion rate was 11.79% (p = 0.011), spanning from 17.31% (p = 0.131) in acute to 7.44% (p = 0.081) in chronic SCI.
Conclusion
Scaffold implantation shows promising neuroregenerative potential, evidenced by AIS grade improvement in human studies. Scaffolds are advancing rapidly from laboratory research to clinical trials, expanding treatment options for SCI.

🔗 https://doi.org/10.1038/s41393-025-01114-9

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🆔 @COTAR_TUMS

🎇مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی (COTAR) برگزار می‌کند:

📚سلسله ژورنال کلاب‌های میان‌رشته‌ای | COTAR COLLAB

🔖موضوع جلسه پنجم :
AI based detection of fractures

📆 سه شنبه ۴ شهریور ۱۴۰۴
⏰ ساعت ۱۲ الی ۱۳
🏛 بیمارستان شریعتی، معاونت آموزشی، کلاس سینا
💻 لینک مجازی:
cotar.tums.ac.ir/webinar

👥 با حضور دکتر نبیان - ریاست مرکز تحقیقات
ارایه دهنده: سهیل رمضانزاده - دانشجوی پزشکی
🧁 همراه با پذیرایی و شبکه‌سازی پس از جلسه
حضور تمامی دانشجویان و پژوهشگران علاقه‌مند گرامی داشته می‌شود.

🎇مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی (COTAR) برگزار می‌کند:

📚سلسله ژورنال کلاب‌های میان‌رشته‌ای | COTAR COLLAB

🔖موضوع جلسه چهارم :
Bone Substitutes in Orthopaedic Surgery
📆 سه شنبه ۲۱ مرداد ۱۴۰۴
⏰ ساعت ۱۲ الی ۱۳
🏛 بیمارستان شریعتی، معاونت آموزشی، کلاس سینا
💻 لینک مجازی:
cotar.tums.ac.ir/webinar

👥 با حضور دکتر نبیان - ریاست مرکز تحقیقات
ارایه دهنده: دکتر علی جهرمی - دارنده مدال طلای جهانی المپیاد شیمی

🧁 همراه با پذیرایی و شبکه‌سازی پس از جلسه
حضور تمامی دانشجویان و پژوهشگران علاقه‌مند گرامی داشته می‌شود.