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COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

@cotar_tums

مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی
وابسته به دانشگاه علوم پزشکی تهران

Center for Orthopedic Trans-Disciplinary Applied Research (COTAR)

⬅️ Previously, Research Center for Neural Repair (RCNR)

🆔 @COTAR_Support

🌐 cotar.tums.ac.ir
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Showing posts older than #138 · Back to latest

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Post #137 557
❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Hypertrophic synovial plica in the lateral side of the knee - A case report: Case report and literature review

👥 Arash Sherafatvaziri, Fardis Vosoughi, Alireza Mirzamohamadi, Erfan Babaei Nejad, Ramin Shayan-Moghadam*

📔 International Journal of Surgery Case Reports (Q3)

🗓 June 2024

🗂 Case report

📄 Abstract: Plicae or synovial folds can be detected in different joints, especially around the knee. Synovial plicae pathologies are rare conditions with difficulty in diagnosis because of various symptoms overlapping with other diseases. We reported a rare case of symptomatic hypertrophic synovial plica in the lateral side of the knee in a 12-year-old boy following a traumatic event almost two years before the surgery. The diagnosis and treatment were conducted by knee arthroscopy, and follow-up of the patients showed significant improvements with no pain or range of motion restrictions. The reported case had a significantly lower age of presentations compared to most previously reported cases, and he was diagnosed with lateral knee hypertrophic plicae, while medial knee hypertrophic plicae are more commonly reported, which is considered rare findings. Contrary to previous studies of lateral plica, our case had a history of significant direct trauma, and he was not a professional athlete. Furthermore, based on evidence, hypertrophic synovial plicae are mostly asymptomatic, but in our case, there was a pain in his knee that worsened in flexion. Physicians should consider the possibility of synovial hypertrophic plicae, especially in younger patients with histories of direct traumatic events.

🔗 https://doi.org/10.1016/j.ijscr.2024.109705

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Post #136 883
❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review

👥 Sepideh Yadegar, Fatemeh Mohammadi, Amirhossein Yadegar, Ali Mohammadi Naeini, Aryan Ayati, Nesa Milan, Amirhossein Tayebi, Seyed Arsalan Seyedi, Seyed Ali Nabipoorashrafi, Soghra Rabizadeh, Alireza Esteghamati, Manouchehr Nakhjavani*

📔 Phytotherapy Research (Q1)

🗓 May 2024

🗂 Review

📄 Abstract: Resveratrol (RSV) has garnered significant attention in recent years due to its potential benefits against chronic diseases. However, its effects and safety in older adults have not been comprehensively studied. This study aimed to determine the effects and safety of RSV supplementation in older adults. MEDLINE/PubMed, Scopus, and Web of Science databases were comprehensively searched for eligible studies. Studies were enrolled if they were randomized clinical trials and had incorporated RSV supplementation for older adults. Two independent authors conducted the literature search, and eligibility was determined according to the PICOS framework. Study details, intervention specifics, and relevant outcomes were collected during the data collection. The Cochrane RoB-2 tool was used to evaluate the risk of bias. This review included 10 studies. The combination of RSV and exercise improved exercise adaptation and muscle function in healthy older adults and physical performance and mobility measures in individuals with functional limitations. RSV showed potential neuroprotective effects in patients with Alzheimer's disease. In overweight individuals, RSV demonstrated a positive impact on cognitive function, but it increased some biomarkers of cardiovascular disease risk at high doses. In older adults with diabetes and those with peripheral artery disease (PAD), RSV was not more effective than placebo. No study reported significant adverse events following RSV treatment. RSV can improve various health parameters in age-related health conditions. However, the optimal dosage, long-term effects, and potential interactions with medications still need to be investigated through well-designed RCTs.

🔗 http://dx.doi.org/10.1002/ptr.8171

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Post #135 882
❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Genetic and Lifestyle Risk Factors of Metabolic Dysfunction-Associated Fatty Liver Disease and Its Relationship with Premature Coronary Artery Disease: A Study on the Pars Cohort

👥 Amir Anushiravani, Maryam Rayatpisheh, Amir Kasaeian*, Iman Menbari Oskouie*

📔 Archives of Iranian Medicine (Q1)

🗓 May 2024

🗂 Original research

📄 Abstract: The main objective of this study is to identify the risk factors of metabolic dysfunction-associated fatty liver disease (MAFLD) in coronary artery disease (CAD) patients. The present retrospective cohort study is part of the Pars Cohort Study (PCS). The participants were categorized as having MAFLD or not. The pattern of independent variables in patients was compared with those who did not have MAFLD. All variables were retained in the multivariable logistic regression model. Totally, 1862 participants with CAD were enrolled in this study. MAFLD was diagnosed in 647 (40.1%) participants. Gender, diabetes, hypertension, tobacco, opium, alcohol, age, weight, waist circumference, cholesterol, HDL, triglyceride, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were significantly different in MAFLD and non-MAFLD patients. Also, the results of multivariable logistic regression show male gender (OR=0.651, 95% CI: 0.470‒0.902, P value=0.01) and opium consumption (OR=0.563, 95% CI: 0.328‒0.968, P value<0.001) to be negative risk factors of MAFLD occurrence in CAD patients. Having diabetes (OR=2.414, 95% CI: 1.740-3.349, P value<0.001), high waist circumference (OR=1.078, 95% CI: 1.055‒1.102, P value<0.01), high triglyceride (OR=1.005, 95% CI: 1.001‒1.008, P value=0.006), and high ALT (OR=1.039, 95% CI: 1.026‒1.051, P value<0.01) were positive risk factors of MAFLD in CAD patients. Our study found that consuming opium decreases the likelihood of MAFLD in CAD patients, since these patients have decreased appetite and lower body mass index (BMI). On the other hand, female gender, having diabetes, high waist circumference, high triglyceride levels, and high ALT levels increase the probability of MAFLD in CAD patients.

🔗 https://doi.org/10.34172/aim.2024.36

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Post #134 816
❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Sleep profiles in epilepsy patients undergoing monotherapy and polytherapy: A comparative cross-sectional study

👥 Alireza Arvin, Morvarid Taebi, Zahra Khazaeipour, Arezu Najafi, Abbas Tafakhori, Sakineh Ranji-Bourachaloo, Hamed Amirifard*

📔 Epilepsy & Behavior (Q2)

🗓 April 2024

🗂 Original research

📄 Abstract: Sleep disturbances commonly reported among epilepsy patients have a reciprocal relationship with the condition; While epilepsy and anti-seizure medications (ASMs) can disrupt sleep structure, disturbed sleep can also exacerbate the frequency of seizures. This study explored subjective sleep disturbances and compared sleep profiles in patients who underwent ASM monotherapy and polytherapy. We enrolled 176 epilepsy patients who completed a structured questionnaire containing demographic and clinical information and the Persian versions of the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and Patient Health Questionnaire-9 (PHQ-9) to evaluate sleep quality, insomnia, excessive daytime sleepiness (EDS), and depressive symptoms, respectively. Chi-square and Mann-Whitney U tests were employed to analyze the association between variables, and logistic regression analysis was conducted to identify factors predicting sleep disturbances. Comparative analysis of mono/polytherapy groups revealed a significantly higher prevalence of insomnia and EDS among patients on polytherapy compared to monotherapy. However, no significant difference was found in sleep quality between the two groups. Logistic regression analysis revealed that a depressive mood serves as a robust predictor for sleep issues, whereas treatment type did not emerge as an independent predictor of sleep disturbances. Our findings suggest that an increased number of ASMs does not inherently result in a higher incidence of sleep issues. Therefore, multiple ASMs may be prescribed when necessary to achieve improved seizure control. Furthermore, this study underscores the importance of comprehensive management that addresses seizure control and treating affective symptoms in individuals with epilepsy.

🔗 https://doi.org/10.1016/j.yebeh.2024.109799

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Post #133 651
❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Machine Learning for prediction of violent behaviors in schizophrenia spectrum disorders: a systematic review

👥 Mohammadamin Parsaei, Alireza Arvin, Morvarid Taebi, Homa Seyedmirzaei, Giulia Cattarinussi, Fabio Sambataro, Alessandro Pigoni, Paolo Brambilla, Giuseppe Delvecchio*

📔 Frontiers in Psychiatry (Q2)

🗓 March 2024

🗂 Review

📄 Abstract: Schizophrenia spectrum disorders (SSD) can be associated with an increased risk of violent behavior (VB), which can harm patients, others, and properties. Prediction of VB could help reduce the SSD burden on patients and healthcare systems. Some recent studies have used machine learning (ML) algorithms to identify SSD patients at risk of VB. In this article, we aimed to review studies that used ML to predict VB in SSD patients and discuss the most successful ML methods and predictors of VB. We performed a systematic search in PubMed, Web of Sciences, Embase, and PsycINFO on September 30, 2023, to identify studies on the application of ML in predicting VB in SSD patients. We included 18 studies with data from 11,733 patients diagnosed with SSD. Different ML models demonstrated mixed performance with an area under the receiver operating characteristic curve of 0.56-0.95 and an accuracy of 50.27-90.67% in predicting violence among SSD patients. Our comparative analysis demonstrated a superior performance for the gradient boosting model, compared to other ML models in predicting VB among SSD patients. Various sociodemographic, clinical, metabolic, and neuroimaging features were associated with VB, with age and olanzapine equivalent dose at the time of discharge being the most frequently identified factors. ML models demonstrated varied VB prediction performance in SSD patients, with gradient boosting outperforming. Further research is warranted for clinical applications of ML methods in this field.

🔗 https://doi.org/10.3389/fpsyt.2024.1384828

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Post #132 634
❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Challenges of Using C-Arm Fluoroscopy Systems: A Mixed Method Study Investigating Orthopedic Surgeons’ Experience

👥 Mobina Gharib, Shakiba Mohammadi*, Mohammadreza Mohammadi, Nastaran Maghbouli, Mohammad Hossein Nabian

📔 Journal of Iranian Medical Council (Q4)

🗓 March 2024

🗂 Original research

📄 Abstract: Intraoperative fluoroscopy systems are widely used nowadays, where their use allows a shorter duration of procedure time and better anatomical localization. The current study aims to investigate the most common challenges of C-arm fluoroscopy systems application. This mixed-method study was carried out in February and March 2022. After the literature review, a qualitative study was designed using semi-structured interviews to find important themes and subthemes required to design a web survey. The web survey was completed by the Persian Orthopedic Trauma Association (POTA) event’s international presenters. Nine orthopedic surgeons participated in interviews and 27 participants filled out the questionnaires. Five main themes including Physical Aspect, Mechanical Aspect, Software Options, Image Quality, and Radiation Exposure were extracted. Generally, over 80% of the web survey participants agreed that the size and shape of the base of C-arm fluoroscopy systems, C-arm diameter (space between tube and detector), and maneuvering and positioning of the C-arm fluoroscopy systems can interfere with surgical procedures. 100% of the participants agreed that providing two different views (e.g., AP and lateral) from the surgical site with one shot can be beneficial. The effectiveness of real-time visualization of radiation exposure on exposure rate was acknowledged by more than 92% of the participants. Although the C-arm fluoroscopy systems are widely used in surgical procedures, there are considerable issues regarding the application of this imaging modality in the operation room, and medical equipment companies should pay more attention to these issues to facilitate the use of these systems.

🔗 https://doi.org/10.18502/jimc.v7i2.15047

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Post #131 602
❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Sex Dimorphism in Pain Threshold and Neuroinflammatory Response: The Protective Effect of Female Sexual Hormones on Behavior and Seizures in an Allergic Rhinitis Model

👥 Mohammad Elahi, Zahra Ebrahim Soltani, Arya Afrooghe, Elham Ahmadi, Ahmad Reza Dehpour

📔 Journal of Neuroimmune Pharmacology (Q1)

🗓 April 2024

🗂 Review

📄 Abstract: Our previous research demonstrated that allergic rhinitis could impact behavior and seizure threshold in male mice. However, due to the complex hormonal cycles and hormonal influences on behavior in female mice, male mice are more commonly used for behavioral tests. In this study, we aimed to determine whether these findings were replicable in female mice and to explore the potential involvement of sexual hormones in regulating neuroinflammation in an allergic model. Our results indicate that pain threshold was decreased in female mice with allergic rhinitis and the levels of IL-23/IL-17A/IL-17R were increased in their Dorsal root ganglia. However, unlike males, female mice with AR did not display neuropsychological symptoms such as learning and memory deficits, depression, and anxiety-like behavior. This was along with decreased levels of DNA methyl transferase 1 (DNMT1) and inflammatory cytokines in their hippocampus. Ovariectomized mice were used to mitigate hormonal effects, and the results showed that they had behavioral changes and neuroinflammation in their hippocampus similar to male mice, as well as increased levels of DNMT1. These findings demonstrate sex differences in how allergic rhinitis affects behavior, pain sensitivity, and seizure thresholds. Furthermore, our data suggest that DNMT1 may be influenced by sexual hormones, which could play a role in modulating inflammation in allergic conditions.

🔗 https://doi.org/10.1007/s11481-024-10114-0

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Post #130 598
❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Intrathecal baclofen efficacy for managing motor function and spasticity severity in patients with cerebral palsy: a systematic review and meta-analysis

👥 Mahdi Masrour, Amir Zare, Ana Presedo*, Mohammad Hossein Nabian*

📔 BMC Neurology (Q2)

🗓 April 2024

🗂 Review

📄 Abstract: Spasticity can significantly affect a patient’s quality of life, caregiver satisfaction, and the financial burden on the healthcare system. Baclofen is one of only a few options for treating spasticity. The purpose of this study is to investigate the impact of intrathecal baclofen (ITB) therapy on severe spasticity and motor function in patients with cerebral palsy. We conducted a systematic review in PubMed, Scopus, Ovid, and the Cochrane Library in accordance with the PRISMA guidelines. We included studies based on eligibility criteria that included desired participants (cerebral palsy patients with spasticity), interventions (intrathecal baclofen), and outcomes (the Ashworth scales and the Gross Motor Function Measure [GMFM]). The within-group Cohen’s d standardized mean differences (SMD) were analyzed using the random effect model. We screened 768 papers and included 19 in the severity of spasticity section and 6 in the motor function section. The pre-intervention average spasticity score (SD) was 3.2 (0.78), and the post-intervention average score (SD) was 1.9 (0.72), showing a 40.25% reduction. The SMD for spasticity reduction was − 1.7000 (95% CI [-2.1546; -1.2454], p-value < 0.0001), involving 343 patients with a weighted average age of 15.78 years and a weighted average baclofen dose of 289 µg/day. The SMD for the MAS and Ashworth Scale subgroups were − 1.7845 (95% CI [-2.8704; -0.6986]) and − 1.4837 (95% CI [-1.8585; -1.1088]), respectively. We found no relationship between the participants’ mean age, baclofen dose, measurement time, and the results. The pre-intervention average GMFM (SD) was 40.03 (26.01), and the post-intervention average score (SD) was 43.88 (26.18), showing a 9.62% increase. The SMD for motor function using GMFM was 0.1503 (95% CI [0.0784; 0.2223], p-value = 0.0030), involving 117 patients with a weighted average age of 13.63 and a weighted average baclofen dose of 203 µg/day. In 501 ITB implantations, 203 medical complications were reported, including six new-onset seizures (2.96% of medical complications), seven increased seizure frequency (3.45%), 33 infections (16.26%), eight meningitis (3.94%), and 16 cerebrospinal fluid leaks (7.88%). Delivery system complications, including 75 catheter and pump complications, were also reported. Despite the risk of complications, ITB has a significant impact on the reduction of spasticity. A small but statistically significant improvement in motor function was also noted in a group of patients.

🔗 https://doi.org/10.1186/s12883-024-03647-7

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Post #129 906
❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Gait and muscle activity measures after biomechanical device therapy in subjects with ankle instability: A systematic review

👥 Hanieh Khaliliyan, Arash Sharafatvaziri, Zahra Safaeepour, Mahmood Bahramizadeh*

📔 Foot (Q2)

🗓 March 2024

🗂 Review

📄 Abstract: Health specialists suggest a conservative approach comprising non-pharmacological interventions as the initial course of action for individuals with repetitive ankle sprain due to ankle instability. This systematic review aimed to assess the effectiveness of biomechanical devices (Foot Orthoses, Ankle Orthoses, and Taping) on gait and muscle activity in individuals with ankle instability. A systematic search was performed on electronic databases, including PubMed, EMBASE, Clinical Trials.gov, Web of Science, and Scopus. The PEDro scoring system was used to evaluate the quality of the included studies. We extracted data from population, intervention, and outcome measures. In the initial search, we found 247 articles. After following the steps of the PRISMA flowchart, only 22 reports met the inclusion criteria of this study. The results show that biomechanical device therapy may increase swing time, stance time, and step. Additionally, studies suggest that these devices can reduce plantar flexion, inversion, and motion variability during gait. Biomechanical devices have the potential to optimize the subtalar valgus moment, push-off, and braking forces exerted during walking, as well as enhance the activity of specific muscles including the peroneus longus, peroneus brevis, tibialis anterior, gluteus medius, lateral gastrocnemius, rectus femoris, and soleus. Biomechanical devices affect gait (spatiotemporal, kinetic, and kinematic variables) and lower limb muscle activity (root mean square, reaction time, amplitude, reflex, and wave) in subjects with ankle instability.

🔗 https://doi.org/10.1016/j.foot.2024.102083

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Post #128 1.12K
❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Hypermobile lateral meniscus: A systematic review of current treatment options

👥 Fardis Vosoughi, Asma Mafhoumi, Mahdi Gouravani, Robert F LaPrade, Arash Sherafat Vaziri, Mohammad Movahedinia, Sohrab Keyhani*

📔 Knee Surgery, Sports Traumatology, Arthroscopy (Q1)

🗓 March 2024

🗂 Review

📄 Abstract: The reliable data on the incidence of hypermobile lateral meniscus (HLM) and its clinical manifestations, diagnostic methods and therapeutic approaches are limited. This systematic study aimed to review available treatment options for HLM and the outcomes of each approach. A systematic search was performed in four electronic databases (PubMed, EMBASE, Scopus, Web of Science) to identify studies in which arthroscopically confirmed cases of HLM were treated surgically or nonsurgically, and the required data comprising study characteristics, patient data, treatment approaches and outcome measures were extracted from eligible studies. Twenty studies with a total of 212 patients (138 males and 74 females) and 219 knees were included. The most frequently reported symptoms were locking sensations, knee pain, giving way and snapping. Treatments used by the studies were: radiofrequency energy in two studies; arthroscopic partial meniscectomy in one study; open surgery in two studies; and arthroscopic meniscal repair in 17 studies. Eleven studies used an all-inside repair method and an inside-out meniscal repair was reported in eight studies. Three studies reported the usage of posterior arthroscopy for therapeutic or diagnostic approaches. Evaluation of symptom resolution was the main outcome measurement for which almost all of the studies stated relief of symptoms after intervention. Despite the lack of definite consensus about the most appropriate intervention for HLM, therapeutic preference was directed towards arthroscopic all-inside and inside-out repair techniques. Although the surgeon's decision remains the key factor in choosing the most suitable treatment option for each individual, posterior arthroscopic meniscal repair may be considered as a better option for HLM treatment according to the findings of this review.

🔗 https://doi.org/10.1002/ksa.12102

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Post #127 1.07K
✳️ فراخوان شورای اجرایی ۱۴۰۳

🔸 دو عنصر اساسی در ساختار مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی (COTAR) وجود دارد: کمیته‌هایی که از اعضای هیئت علمی تشکیل شده‌اند و به شورای پژوهشی معروف هستند و شورای اجرایی که از پژوهشگران ارشد و رئیس مرکز تشکیل شده‌اند. تمامی موفقیت‌ها و پیشرفت‌هایی که مرکز تاکنون داشته است، نتیجه‌ی تلاش‌ها و حضور مداوم این دو رکن بوده است.

🔹 اکنون با آغاز سال جدید، قرار است شورای اجرایی نیز اعضای جدید خود را بشناسد. به همین منظور، از تمامی دانشجویان و فارغ‌التحصیلان کوتاری دغدغه‌مند دعوت می‌شود تا با ثبت‌نام از طریق فرم زیر، آمادگی خود را جهت عضویت در این شورا اعلام نمایند:
🔗 https://forms.formool.ir/6hl69

❓ جهت اطلاع از سازوکار، نقش‌ها و وظایف اعضای شورای اجرایی، لطفا سند زیر را مطالعه نمایید:
https://cotar.tums.ac.ir/InfrastructureDoc

⏰ مهلت ثبت‌نام: سه شنبه ۲۹ اسفند ۱۴۰۲، ساعت ۲۳:۵۹

🌱 امید است که با تداوم این چرخه، پرقدرت به مسیر ادامه دهیم.

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  • ❤ 1
Post #126 893
❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Distal femoral osteotomy and patellar tendon advancement for the treatment of crouch gait in patients with bilateral spastic cerebral palsy

👥 Mohammad Hossein Nabian, Shayan Abdollah Zadegan, Cindy Mallet, Yamile Neder, Brice Ilharreborde, Anne Laure Simon, Ana Presedo*

📔 Gait & Posture (Q1)

🗓 March 2024

🗂 Original research

📄 Abstract: Crouch gait, or flexed knee gait, represents a common gait pattern in patients with spastic bilateral cerebral palsy (CP). Distal femoral extension and/or shortening osteotomy (DFEO/DFSO) and patellar tendon advancement (PTA) can be considered as viable options when knee flexion contractures are involved. Better outcomes have been reported after a combination of both, independently of the presence of knee extensor lag. In this study, we evaluated the clinical and kinematic outcomes of these procedures. We reviewed a cohort of 52 limbs (28 patients) who were treated for crouch gait by DFEO/DFSO alone (group 1, n = 15) or DFEO/DFSO + PTA (group 2, n = 37) as a part of single event multilevel surgery (SEMLS). The mean age at surgery was 14 years, and the mean follow-up time was 18 months. The physical examination data and three-dimensional standardized gait analysis were collected and analyzed before the surgery and postoperatively. Overall knee range of motion improved in all limbs. The knee flexion decreased significantly in both groups at initial, mid, and terminal stance. Hip flexion significantly decreased in mid-stance for limbs in group 2. Both clinical and gait parameters were most improved in limbs who underwent DFEO/DFSO + PTA. Increased pelvic tilt was observed in both groups after surgery. Although DFEO/DFSO alone was successful in correcting knee flexion contractures, PTA has helped to improve knee extensor lag and knee extension during gait.

🔗 https://doi.org/10.1016/j.gaitpost.2024.02.019

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Post #123 897
❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Non-coding RNAs as potential therapeutic targets for receptor tyrosine kinase signaling in solid tumors: current status and future directions

👥 Aysan Moeinafshar, Mohammad Nouri, Nima Shokrollahi, Mahdi Masrour, Amirmohammad Behnam, Sahand Tehrani Fateh, Hossein Sadeghi, Mohammad Miryounesi & Mohammad-Reza

📔 Cancer Cell International (Q1)

🗓 January 2024

🗂 Review

📄 Abstract: This review article presents an in-depth analysis of the current state of research on receptor tyrosine kinase regulatory non-coding RNAs (RTK-RNAs) in solid tumors. RTK-RNAs belong to a class of non-coding RNAs (nc-RNAs) responsible for regulating the expression and activity of receptor tyrosine kinases (RTKs), which play a critical role in cancer development and progression. The article explores the molecular mechanisms through which RTK-RNAs modulate RTK signaling pathways and highlights recent advancements in the field. This include the identification of potential new RTK-RNAs and development of therapeutic strategies targeting RTK-RNAs. While the review discusses promising results from a variety of studies, encompassing in vitro, in vivo, and clinical investigations, it is important to acknowledge the challenges and limitations associated with targeting RTK-RNAs for therapeutic applications. Further studies involving various cancer cell lines, animal models, and ultimately, patients are necessary to validate the efficacy of targeting RTK-RNAs. The specificity of ncRNAs in targeting cellular pathways grants them tremendous potential, but careful consideration is required to minimize off-target effects, the article additionally discusses the potential clinical applications of RTK-RNAs as biomarkers for cancer diagnosis, prognosis, and treatment. In essence, by providing a comprehensive overview of the current understanding of RTK-RNAs in solid tumors, this review emphasizes their potential as therapeutic targets for cancer while acknowledging the associated challenges and limitations.

🔗 https://doi.org/10.1186/s12935-023-03203-2

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Post #121 9.1K
✳️ کارگاه مبانی مقاله‌نویسی در علوم پزشکی

✏️ با تدریس دکتر شاهین آخوندزاده، استاد دانشگاه علوم پزشکی تهران و پژوهشگر ۱٪ پر استناد برتر دنیا

🗓 پنج‌شنبه ۲۶ بهمن و ۱۷ اسفند ۱۴۰۲، ساعت ۸ الی ۱۲ صبح

👥 به صورت هیبرید (حضوری + مجازی)

🏛 محل برگزاری: بیمارستان شریعتی

📄 همراه با ارائه گواهی‌نامه حضور در کارگاه

❇️ فیلم جلسات برگزار شده به صورت ضبط‌شده در اختیار ثبت‌نام‌کنندگان قرار می‌گیرد.

♨️ کد تخفیف ۳۰ درصدی:
cotar_tums

🔻 ثبت‌نام و اطلاعات بیشتر:
cotar.tums.ac.ir/sww

🆔 @Orthopedic_Association
🆔 @COTAR_TUMS
Post #117 732
COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی ✳️ کارگاه کشت سلول آزمایشگاهی ♨️ آموزش فعالیت‌محور کشت سلول 🔸 بخش نظری: چهارشنبه و پنج‌شنبه ۱۰ و ۱۱ آبان ماه ۱۴۰۲، ساعت ۱۶ تا ۱۸ 🔹 بخش عملی: اواسط دی ماه ۱۴۰۲ 🏛 مکان: خیابان ولیعصر، بالاتر از بلوار میرداماد، خیابان رشید یاسمی، بیمارستان خاتم الانبیا، مرکز…
📷 برگزاری بخش عملی کارگاه کشت سلول آزمایشگاهی

🗓 ۱۳ دی ماه ۱۴۰۲
🏛 ساختمان مرکز تحقیقات شفا

🆔 @COTAR_TUMS
Post #116 828
🎗 #افتخار جدید: مرکز برگزیده در آیین تجلیل از پژوهشگران، فناوران و واحد‌های برگزیده دانشگاه

♨️ بدین وسیله برگزیده شدن مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی برای حیطه اثرات فراآکادمیک در آئین تجلیل از پژوهشگران، فناوران و واحد‌های برگزیده دانشگاه علوم پزشکی تهران که در تاریخ ۱۳ دی ماه ۱۴۰۲ در تالار دارالفنون ساختمان ستاد مرکزی برگزار شد، را به خانواده پرتلاش کوتار تبریک عرض می‌نماییم.

🌱 به امید حرکت به سمت هدف اصلی پژوهش‌ها.
Post #115 806
❇️ انتشار #مقاله جدید با وابستگی کوتار توسط انتشارات Nature

💠 Cadaveric biomechanical assessment of different configurations for a novel pin and plate fixation method in distal humerus fractures

👥 Kaveh Same, Alireza Hakiminejad, Amir Nourani, Mohammad Hossein Nabian, Mehdi Foruozesh, Reza Shahriar Kamrani*

📔 Scientific Reports (Q1)

🗓 January 2024

🗂 Original Research

📄 Abstract: Use of dual pre-contoured plates has been accepted as the treatment of choice in distal humerus fractures despite challenges especially in very distal or highly fragmented fractures. Aiming to improve results in such instances, our newly proposed method uses several K-wires fixated by a small reconstruction plate. Drawing on the results of previous finite element studies, the current study aims to compare the stiffness of three clinically common variations of this method using biomechanical testing in cadaveric humeri. 24 samples were divided into three groups and fractures were simulated. Groups I and II used 1.5 mm K-wires in differing configurations while 2 mm wires were used in group III. All samples underwent compression, anterior and posterior bending, and torsional testing as well as failure testing. Our results indicated that Group III had significantly higher stiffness in flexion, extension, and torsion (p < 0.05). In failure, group III had the highest mean stiffness in anterior bending and torsion (861.2 N, 30.9 Nm). Based on previous and current results, this new Persian fixation method, especially when implemented using 2 mm K-wires, shows promise in achieving suitable stability and may be useful as an alternative approach in complex distal humerus fractures.

🔗 https://doi.org/10.1038/s41598-023-50976-7

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